Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.35 |
| ▸ | KIT | P10721 | 5/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116749 | 0.85 | NR1H4 (0.45) | GRM5NR1H4PTGER3HTR4 | |
| SCHEMBL20116453 | 0.83 | HDAC8 (0.37) | GRM5KITPTGER3 | |
| SCHEMBL22358291 | 0.81 | GPR119 (0.45) | GRM5 | |
| SCHEMBL20116940 | 0.81 | NR1H4 (0.41) | GRM5KITPIK3CDNR1H4PTGER3 | |
| SCHEMBL20116449 | 0.81 | GRM5 (0.37) | GRM5KITPTGER3 | |
| SCHEMBL20676634 | 0.80 | NR1H4 (0.40) | KITNR1H4 | |
| SCHEMBL20116100 | 0.80 | LDHA (0.41) | GRM5KITNR1H4 | |
| SCHEMBL20116694 | 0.79 | GRM5 (0.36) | GRM5KITPTGER3 | |
| SCHEMBL20117297 | 0.79 | KIT (0.37) | GRM5KITNR1H4PTGER3HTR4 | |
| SCHEMBL20116733 | 0.78 | SCD5 (0.36) | GRM5KITNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |