Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116690 | 0.88 | GRM5 (0.54) | GRM5ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL20116662 | 0.86 | GRM5 (0.44) | GRM5ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL20676706 | 0.85 | SMN1; SMN2 (0.43) | GRM5ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL20116838 | 0.84 | LMNA (0.54) | GRM5ALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL20117192 | 0.83 | TLR9 (0.51) | ALDH1A1NPSR1TSHRHTTSMN1; SMN2 | |
| SCHEMBL20676642 | 0.83 | SMN1; SMN2 (0.42) | ALDH1A1TSHRHTTSMN1; SMN2LMNA | |
| SCHEMBL20116791 | 0.82 | SMO (0.43) | GRM5ALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL20116798 | 0.82 | KIT (0.42) | NPSR1MEN1KMT2ATSHRHTT | |
| SCHEMBL20116828 | 0.81 | KIT (0.44) | GRM5NPSR1MEN1KMT2ATSHR | |
| SCHEMBL20116859 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1TSHRHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |