Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116859 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116690 | 0.85 | GRM5 (0.54) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116798 | 0.84 | KIT (0.42) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20117284 | 0.84 | SMO (0.42) | SMN1; SMN2HTTGAASMO | |
| SCHEMBL20116847 | 0.84 | NPC1 (0.42) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116836 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116838 | 0.83 | LMNA (0.54) | SMN1; SMN2LMNATSHRHTTSMO | |
| SCHEMBL20116753 | 0.83 | GRM5 (0.54) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20676642 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116682 | 0.82 | NPC1 (0.53) | SMN1; SMN2LMNAHTTGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |