Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676205 | 0.84 | JAK1 (0.40) | PIK3CDJAK1JAK2CCNCCDK8 | |
| SCHEMBL22358040 | 0.81 | KCNH2 (0.40) | PIK3CDJAK1JAK2CCNCCDK8 | |
| SCHEMBL15440769 | 0.81 | DDB1 (0.43) | PIK3CDJAK1JAK2KDM4CPDE1A | |
| SCHEMBL20116281 | 0.76 | PDE1A (0.44) | PIK3CDPDE1APDE1BPDE1CPDE4D | |
| SCHEMBL20116882 | 0.76 | PDE1A (0.44) | PIK3CDPDE1APDE1BPDE1CPDE4D | |
| SCHEMBL20116287 | 0.76 | PDE1A (0.44) | PIK3CDPDE1APDE1BPDE1CPDE4D | |
| SCHEMBL21786656 | 0.75 | RXRA (0.50) | PIK3CD | |
| SCHEMBL30236474 | 0.75 | RXRA (0.50) | PIK3CD | |
| SCHEMBL411900 | 0.73 | PDE9A (0.38) | PIK3CD | |
| SCHEMBL22358076 | 0.73 | PIK3CD (0.41) | PIK3CDPDE1APDE1BPDE1CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |