SCHEMBL2011706

SCHEMBL2011706

CCOC(=O)CN1Cc2cc(C(=N)NO)ccc2C1=O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.47
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
ITGB3 P05106 4/20 0.43
ITGA2B P08514 4/20 0.43
AOC3 Q16853 2/20 0.43
PIN1 Q13526 1/20 0.42
PIN4 Q9Y237 1/20 0.42
HRH4 Q9H3N8 1/20 0.39
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HDAC6 Q9UBN7 1/20 0.37
LMNA P02545 1/20 0.36
TNF P01375 1/20 0.36
CA12 O43570 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2008615 0.86 ITGB3 (0.43) KMT2AMEN1ITGB3ITGA2BAOC3
SCHEMBL2009666 0.85 ITGB3 (0.38) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2008739 0.83 ITGB3 (0.41) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2007548 0.83 ITGB3 (0.37) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2011006 0.83 GAA (0.37) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2014008 0.83 ITGB3 (0.42) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2008734 0.83 ITGB3 (0.46) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2011860 0.82 ITGB3 (0.36) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2010377 0.82 ITGB3 (0.42) ALOX15KMT2AMEN1ITGB3ITGA2B
SCHEMBL2012100 0.82 HPGD (0.45) ALOX15KMT2AMEN1ITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964628-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-06-21 US disclosed
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-10-07 US disclosed
US-7759387-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-07-20 US disclosed
US-20070021489-A1 Fibrinogen receptor antagonists and their use NICHOLAS PIRAMAL INDIA LIMITED (IN) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE FGB, F13B, F2 ALOX15 2131/4885KMT2A 4561/4885MEN1 4472/4885
US-20070021489-A1 Fibrinogen receptor antagonists and their use FGB, F13B, F2 ALOX15 2131/4885KMT2A 4561/4885MEN1 4472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.