Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118414 | 0.86 | TNKS (0.55) | KDM4EHSD17B10TNKSHTTIRAK4 | |
| SCHEMBL20118188 | 0.80 | KDM4E (0.47) | KDM4EHSD17B10TNKSIRAK4PKM | |
| SCHEMBL18208125 | 0.79 | KDM4E (0.50) | KDM4EHSD17B10TNKSHTTIRAK4 | |
| SCHEMBL18208122 | 0.79 | KDM4E (0.50) | KDM4EHSD17B10TNKSHTTIRAK4 | |
| SCHEMBL20118183 | 0.78 | KDM4E (0.45) | KDM4EHSD17B10TNKSIRAK4IRAK1 | |
| SCHEMBL20118057 | 0.75 | BCL2A1 (0.34) | HSD11B1 | |
| SCHEMBL18208215 | 0.74 | JAK2 (0.52) | KDM4EHSD17B10TNKSIRAK4PKM | |
| SCHEMBL18208212 | 0.74 | JAK2 (0.52) | KDM4EHSD17B10TNKSIRAK4PKM | |
| SCHEMBL20118064 | 0.74 | JAK2 (0.51) | KDM4EHSD17B10TNKSIRAK4PKM | |
| SCHEMBL20118238 | 0.74 | JAK2 (0.51) | KDM4EHSD17B10TNKSIRAK4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |