Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19627524 | 1.00 | CTSK (0.51) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL28469457 | 0.89 | CTSK (0.55) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL11601279 | 0.88 | CTSK (0.44) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL28461096 | 0.87 | CTSK (0.54) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL28461097 | 0.87 | CTSK (0.54) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL20118484 | 0.87 | CTSK (0.54) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL15825083 | 0.86 | CTSK (0.52) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL22605227 | 0.86 | CTSK (0.52) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL30275489 | 0.86 | CTSK (0.52) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL15825084 | 0.86 | CTSK (0.52) | CTSKCTSSCA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532057-B1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARM INC (US) | 2022-12-21 | — | — | EP | disclosed |
| CN-108948084-B | Tenofovir di-L-amino acid ester and preparation method thereof | 浙江司太立制药股份有限公司 | 2020-10-20 | — | — | CN | disclosed |
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |