Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28461096 | 1.00 | CTSK (0.54) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL28461097 | 1.00 | CTSK (0.54) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL28469162 | 0.90 | CTSK (0.58) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL20118340 | 0.87 | CTSK (0.51) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL19627524 | 0.87 | CTSK (0.51) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL8466501 | 0.85 | CTSS (0.59) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL8466502 | 0.85 | CTSS (0.59) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL3729856 | 0.84 | CTSS (0.56) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL3730087 | 0.84 | CTSK (0.58) | CTSKCTSSPSENENCA2CA1 | |
| SCHEMBL3730085 | 0.84 | CTSK (0.58) | CTSKCTSSPSENENCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532057-B1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARM INC (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |