SCHEMBL2011955

SCHEMBL2011955

Cc1c(Cl)cc(CC=O)c(O)c1Br

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 3/20 0.36
TP53 P04637 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
HIF1A Q16665 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ERN1 O75460 3/20 0.32
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
HSD17B10 Q99714 1/20 0.31
ALOX5 P09917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22047603 0.82 CYP2C9 (0.36) TP53CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9953135 0.80 IMPDH2 (0.36) IMPDH2TP53CYP2C9CYP2C19HIF1A
SCHEMBL9952114 0.80 MEP1A (0.33) ERN1
SCHEMBL9952133 0.80 IMPDH2 (0.33) IMPDH2TP53CYP2C9CYP2C19HIF1A
SCHEMBL9952629 0.79 IMPDH2 (0.47) IMPDH2SMN1; SMN2KMT2AALDH1A1CYP1A2
SCHEMBL16345435 0.77 MEN1 (0.36) HIF1AERN1MEN1MAPTKMT2A
SCHEMBL14742187 0.76 IMPDH2 (0.36) IMPDH2CYP2C9CYP2C19SMN1; SMN2KMT2A
SCHEMBL2013694 0.75 GRIN2D (0.40) IMPDH2CYP2C9HIF1AALDH1A1CYP1A2
SCHEMBL9951856 0.74 AR (0.34) IMPDH2MEN1KMT2AALDH1A1
SCHEMBL9952857 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015191677-A1 BICYCLIC HETEROARYLAMINOALKYL PHENYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2015-12-17 WO disclosed
EP-2751109-A1 HETEROCYCLYLAMINES AS PI3K INHIBITORS Incyte Corporation (US) 2014-07-09 EP disclosed
EP-2655374-A1 N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS Incyte Corporation (US) 2013-10-30 EP disclosed
WO-2013151930-A1 BICYCLIC AZAHETEROCYCLOBENZYLAMINES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2013-10-10 WO disclosed
WO-2013033569-A1 HETEROCYCLYLAMINES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2013-03-07 WO disclosed
WO-2012135009-A1 PYRIMIDINE-4,6-DIAMINE DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2012-10-04 WO disclosed
WO-2012087881-A1 N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2012-06-28 WO disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 WO disclosed