Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30850747 | 0.81 | MAPK8 (0.42) | XDHMAPK8MAPK9MAPK10CCNA2 | |
| SCHEMBL30850796 | 0.79 | MAPK8 (0.41) | XDHMAPK8MAPK9MAPK10HCAR1 | |
| SCHEMBL30479324 | 0.79 | TYRO3 (0.42) | XDHMTORTLR7NLRP3DRD4 | |
| SCHEMBL1982195 | 0.78 | PDE9A (0.42) | MAPK8MAPK9MAPK10ALDH1A1LMNA | |
| SCHEMBL4724993 | 0.75 | MAPK8 (0.38) | XDHMAPK8MAPK9MAPK10HCAR1 | |
| SCHEMBL17910173 | 0.75 | RIPK2 (0.47) | MAPK8MAPK9MAPK10HCAR1MTOR | |
| SCHEMBL16993087 | 0.73 | MAPK8 (0.55) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL30850695 | 0.73 | MAPK8 (0.42) | MAPK8MAPK9MAPK10HCAR1MTOR | |
| SCHEMBL25258670 | 0.72 | ACACB (0.39) | MAPK8MAPK9MAPK10HCAR1HTR1A | |
| SCHEMBL25302241 | 0.72 | ACACB (0.39) | MAPK8MAPK9MAPK10HCAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074122-B9 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2013-09-11 | — | — | EP | disclosed |
| EP-2074122-B1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2011-06-29 | — | — | EP | disclosed |