Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | CCNH | P51946 | 3/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30850695 | 0.93 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL30850687 | 0.91 | MAPK8 (0.41) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL30850747 | 0.88 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL17910173 | 0.83 | RIPK2 (0.47) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL30850566 | 0.81 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL2011959 | 0.79 | XDH (0.39) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL16993087 | 0.77 | MAPK8 (0.55) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL30850751 | 0.74 | HTR5A (0.47) | HTR5ARIPK2MAPK1SCN5A | |
| SCHEMBL16993211 | 0.74 | MKNK1 (0.48) | MAPK8CCNA2CDK2MAPK1 | |
| SCHEMBL3052427 | 0.74 | MAPK8 (0.60) | MAPK8MAPK9MAPK10CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162882-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | PRINCIPIA BIOPHARMAC, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-20240092777-A1 | Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2024-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162882-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | FGFR1, FGFR3, FGFR2 | MAPK8 1348/4885MAPK9 1181/4885MAPK10 1825/4885 |
| US-20240092777-A1 | Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors | FGFR1, FGFR3, FGFR2 | MAPK8 1348/4885MAPK9 1181/4885MAPK10 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.