Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993371 | 0.81 | ALDH1A1 (0.53) | MAPK8MAPK9MAPK10CYP1A2HIF1A | |
| SCHEMBL30479302 | 0.79 | PDE9A (0.42) | PDE9AGRIN1GRIN2BCYP1A2CYP3A4 | |
| SCHEMBL2011959 | 0.78 | XDH (0.39) | PDE9AMAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL30703742 | 0.73 | QPCT (0.40) | PDE9ACYP1A2CYP3A4HIF1AALDH1A1 | |
| SCHEMBL22652309 | 0.70 | MAPK8 (0.39) | MAPK8MAPK9MAPK10ALDH1A1MAPK1 | |
| SCHEMBL16993219 | 0.70 | MAPK8 (0.51) | MAPK8MAPK9MAPK10 | |
| SCHEMBL19868139 | 0.70 | CDK2 (0.61) | MAPK8MAPK9MAPK10 | |
| SCHEMBL28066954 | 0.68 | ADORA2A (0.39) | PDE9ACYP1A2CYP3A4HCAR3ALDH1A1 | |
| SCHEMBL28066916 | 0.68 | PDE8B (0.39) | CYP1A2CYP3A4HIF1AALDH1A1KMT2A | |
| SCHEMBL19019072 | 0.67 | PDE3B (0.38) | MAPK8MAPK9MAPK10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074122-B9 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2013-09-11 | — | — | EP | disclosed |
| EP-2074122-B1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2011-06-29 | — | — | EP | disclosed |