Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 6/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
| ▸ | DRD3 | P35462 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18254991 | 0.87 | CLPP (0.89) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL21418081 | 0.84 | CLPP (0.75) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254980 | 0.83 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL29595454 | 0.83 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254989 | 0.83 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| Dordaviprone SCHEMBL16227974 | 0.83 | CLPP (1.00) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| Dordaviprone SCHEMBL29359574 | 0.83 | CLPP (1.00) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| Dordaviprone SCHEMBL29414943 | 0.82 | CLPP (0.98) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| Dordaviprone SCHEMBL31548590 | 0.82 | CLPP (0.98) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254995 | 0.82 | CLPP (0.82) | CLPPCYP3A4GPR132CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3315498-A1 | IMIDAZO-PYRIMIDONE COMPOUNDS, AND PREPARATION METHOD AND APPLICATION THEREOF | Nanjing Gator Meditech Company, Ltd. (CN) | 2018-05-02 | — | — | EP | disclosed |