Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.42 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ASPH | Q12797 | 2/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680085 | 0.81 | KDM4E (0.43) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL17712841 | 0.80 | SIRT6 (0.64) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL1760254 | 0.79 | KDM4E (0.43) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL991478 | 0.79 | KDM4E (0.42) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL16598220 | 0.79 | KDM4E (0.44) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL30954340 | 0.79 | KDM4E (0.44) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL70035 | 0.79 | KDM4E (0.59) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| Hydrochloric Acid SCHEMBL7428212 | 0.78 | KDM4E (0.42) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL16615936 | 0.77 | MAPK1 (0.47) | SIRT6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31390521 | 0.77 | MAPK1 (0.47) | SIRT6KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963434-B2 | N-arylmethyl sulfonamide negative modulators of NR2A | LUC THERAPEUTICS, INC. (US) | 2018-05-08 | — | — | US | disclosed |