Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 7/20 | 0.42 |
| ▸ | ASPH | Q12797 | 2/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680085 | 0.81 | KDM4E (0.43) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL20121341 | 0.79 | SIRT6 (0.44) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL30954340 | 0.79 | KDM4E (0.44) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL16598220 | 0.79 | KDM4E (0.44) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL1760254 | 0.79 | KDM4E (0.43) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL70035 | 0.79 | KDM4E (0.59) | KDM4EHCAR2NAPRTP4HTMASPH | |
| Hydrochloric Acid SCHEMBL7428212 | 0.78 | KDM4E (0.42) | KDM4EHCAR2NAPRTP4HTMASPH | |
| SCHEMBL6917612 | 0.77 | MAPK1 (0.47) | KDM4EALDH1A1SIRT6HPGDHSD17B10 | |
| SCHEMBL27940310 | 0.77 | AGBL2 (0.38) | KDM4ENAPRTP4HTMALDH1A1HSD17B10 | |
| SCHEMBL7767700 | 0.77 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470915-B | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | 霍夫曼-拉罗奇有限公司 | 2019-07-26 | — | — | CN | claimed |
| EP-2864324-B1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-28 | — | — | EP | claimed |
| US-9181232-B2 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2015-11-10 | — | — | US | claimed |
| US-20150133440-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-05-14 | — | — | US | claimed |
| EP-2864324-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-29 | — | — | EP | claimed |
| CN-104470915-A | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | claimed |
| WO-2014001228-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-03 | — | — | WO | claimed |
| CN-104470915-B | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | 霍夫曼-拉罗奇有限公司 | 2019-07-26 | — | — | CN | disclosed |
| EP-2864324-B1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-28 | — | — | EP | disclosed |
| CN-106632401-A | Methods and compounds for the synthesis of fused aminodihydrothiazine derivatives | 卫材R&D管理有限公司 | 2017-05-10 | — | — | CN | disclosed |
| EP-2807155-B1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |
| EP-2665716-B1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |
| US-20120190672-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| WO-2012098213-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012100179-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098213-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | disclosed |
| EP-2456774-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190672-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, APP, BACE2 | KDM4E 655/4885HCAR2 2437/4885NAPRT 3696/4885 |
| US-20150133440-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | BACE1, BACE2, PSEN1 | KDM4E 1439/4885HCAR2 2682/4885NAPRT 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.