Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10682199 | 0.89 | MAPT (0.51) | MAPTKDM4EALDH1A1CNR2CA1 | |
| SCHEMBL19826010 | 0.86 | CA12 (0.55) | ALDH1A1CNR2CA1CA2CA12 | |
| SCHEMBL23971107 | 0.86 | CA12 (0.46) | MAPTKDM4EALDH1A1CA1CA2 | |
| SCHEMBL23159630 | 0.83 | CNR2 (0.48) | MAPTKDM4EALDH1A1CNR2CA1 | |
| SCHEMBL18940647 | 0.81 | KDM4E (0.49) | MAPTKDM4EALDH1A1CNR2CA1 | |
| SCHEMBL27255559 | 0.81 | KDM4E (0.45) | MAPTKDM4EALDH1A1CNR2CA1 | |
| SCHEMBL31160040 | 0.81 | POLB (0.40) | MAPTKDM4EALDH1A1CNR2CA1 | |
| Hydrochloric Acid SCHEMBL18940563 | 0.80 | KDM4E (0.47) | MAPTKDM4EALDH1A1CNR2CA1 | |
| Hydrochloric Acid SCHEMBL31215291 | 0.80 | KDM4E (0.47) | MAPTKDM4EALDH1A1CNR2CA1 | |
| SCHEMBL21343994 | 0.79 | MAPT (0.43) | MAPTKDM4EALDH1A1CNR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963448-B2 | Bicyclic inhibitors of PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-05-08 | — | — | US | disclosed |