Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10682199 | 0.85 | MAPT (0.51) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL21729793 | 0.81 | GAA (0.50) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL23159630 | 0.79 | CNR2 (0.48) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL20121418 | 0.79 | MAPT (0.46) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL18940647 | 0.78 | KDM4E (0.49) | MAPTCNR2KDM4EALDH1A1CA1 | |
| Hydrochloric Acid SCHEMBL18940563 | 0.76 | KDM4E (0.47) | MAPTCNR2KDM4EALDH1A1CA1 | |
| Hydrochloric Acid SCHEMBL31215291 | 0.76 | KDM4E (0.47) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL24422981 | 0.76 | MAPT (0.58) | MAPTKDM4EALDH1A1CA1CA2 | |
| SCHEMBL22872098 | 0.73 | CA1 (0.46) | MAPTCNR2KDM4EALDH1A1CA1 | |
| SCHEMBL15551607 | 0.73 | VCAM1 (0.48) | MAPTKDM4EALDH1A1CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703741-B2 | Covalent inhibitors of PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190276432-A1 | COVALENT INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS INC (US) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703741-B2 | Covalent inhibitors of PAD4 | PADI4, PADI1, PADI6 | MAPT 3994/4885CNR2 4700/4885KDM4E 45/4885 |
| US-20190276432-A1 | COVALENT INHIBITORS OF PAD4 | PADI4, PADI1, PADI6 | MAPT 3994/4885CNR2 4700/4885KDM4E 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.