SCHEMBL20121519

SCHEMBL20121519

CC(N)c1ccc(-c2ccc(-c3ccc(N)cc3)c(F)c2F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.41
CIT O14578 1/20 0.39
PDE2A O00408 1/20 0.38
ALDH1A1 P00352 3/20 0.36
TP53 P04637 2/20 0.36
CYP3A4 P08684 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
GRIA4 P48058 1/20 0.34
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
MAPT P10636 3/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
KDM4E B2RXH2 2/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
APP P05067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29225750 0.82 ALDH1A1 (0.55) ADRB2CITPDE2AALDH1A1TP53
SCHEMBL29225752 0.82 ALDH1A1 (0.55) ADRB2CITPDE2AALDH1A1TP53
SCHEMBL9478914 0.82 ALDH1A1 (0.53) ALDH1A1TP53CYP3A4TDP1ALOX5AP
SCHEMBL18866856 0.81 SLC6A4 (0.43) ALDH1A1TP53CYP3A4TDP1ALOX5AP
SCHEMBL342044 0.79 ADRB2 (0.59) ADRB2PDE2AALDH1A1TP53CYP3A4
SCHEMBL3555995 0.79 ADRB2 (0.59) ADRB2PDE2AALDH1A1TP53CYP3A4
SCHEMBL4208264 0.79 ADRB2 (0.59) ADRB2PDE2AALDH1A1TP53CYP3A4
Hydrochloric Acid SCHEMBL6801092 0.77 ADRB2 (0.56) ADRB2PDE2AALDH1A1TP53CYP3A4
Hydrochloric Acid SCHEMBL6795220 0.77 ADRB2 (0.56) ADRB2PDE2AALDH1A1TP53CYP3A4
Hydrochloric Acid SCHEMBL3175939 0.77 ADRB2 (0.56) ADRB2PDE2AALDH1A1TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9963636-B2 Liquid crystal composition and liquid crystal display device using same DIC CORPORATION (JP) 2018-05-08 US disclosed