Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | MIF | P14174 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12510077 | 0.81 | HPGD (0.35) | TSHRLMNATGFBR1MIFHPGD | |
| SCHEMBL24408206 | 0.77 | TGFBR1 (0.32) | TSHRLMNATGFBR1HPGDDRD2 | |
| SCHEMBL24995675 | 0.77 | MIF (0.43) | TSHRTGFBR1MIFHPGDCYP1A2 | |
| SCHEMBL10001044 | 0.77 | PTPN2 (0.34) | TSHRTGFBR1MIFCYP1A2CYP2C9 | |
| SCHEMBL14791070 | 0.73 | — | — | |
| SCHEMBL13220806 | 0.73 | PTPN1 (0.49) | TSHRLMNAHPGDCYP1A2CYP2C9 | |
| SCHEMBL10001046 | 0.73 | JAK2 (0.42) | PIK3CAEGFRMAP4K4 | |
| SCHEMBL22611735 | 0.73 | AHR (0.34) | TSHRMIFCYP1A2CYP2C9MEN1 | |
| SCHEMBL28381150 | 0.73 | MAP4K4 (0.32) | TSHRMIFCYP1A2CYP2C9MEN1 | |
| SCHEMBL10001045 | 0.73 | EGFR (0.33) | TSHRTGFBR1MIFPIK3CACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963462-B2 | Sepiapterin reductase inhibitors | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2018-05-08 | — | — | US | disclosed |