Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28381150 | 0.77 | MAP4K4 (0.32) | EGFRMAP4K4MEN1PDE5AALDH1A1 | |
| SCHEMBL10001044 | 0.77 | PTPN2 (0.34) | EGFRTGFBR1TGFBR2MAP4K4MEN1 | |
| SCHEMBL10001046 | 0.77 | JAK2 (0.42) | EGFRMAP4K4PIK3CA | |
| SCHEMBL22611735 | 0.77 | AHR (0.34) | EGFRMAP4K4MEN1PDE5AALDH1A1 | |
| SCHEMBL23241449 | 0.77 | PTPN1 (0.42) | EGFRTGFBR1TGFBR2MAP4K4MEN1 | |
| SCHEMBL10001043 | 0.77 | TGFBR1 (0.33) | EGFRTGFBR1TGFBR2MAP4K4MEN1 | |
| SCHEMBL18701491 | 0.73 | NPSR1 (0.33) | TGFBR1MAP4K4MEN1PDE5AALDH1A1 | |
| SCHEMBL20121983 | 0.73 | TSHR (0.37) | EGFRTGFBR1MAP4K4MEN1PDE5A | |
| SCHEMBL28378560 | 0.73 | TGFBR1 (0.39) | TGFBR1TGFBR2MAP4K4MEN1PDE5A | |
| SCHEMBL14104156 | 0.69 | AHR (0.43) | EGFRTGFBR1TGFBR2MEN1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148523-B2 | Intermediates useful in preparing certain pyrrolotriazine compounds and a process for making the intermediates | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148523-B2 | Intermediates useful in preparing certain pyrrolotriazine compounds and a process for making the intermediates | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| EP-2111405-B1 | INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES | BRISTOL MYERS SQUIBB CO (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2008086264-A1 | INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-17 | — | — | WO | disclosed |