Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122727 | 0.83 | DYRK1A (0.46) | DYRK1AKDM4ELMNAHTT | |
| SCHEMBL20122843 | 0.77 | MAOA (0.49) | DYRK1AGSK3BKDM4EMEN1ALDH1A1 | |
| SCHEMBL21326106 | 0.77 | DYRK1A (0.52) | DYRK1AKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL20122824 | 0.73 | DYRK1A (0.55) | DYRK1AGSK3BKDM4EMEN1ALDH1A1 | |
| SCHEMBL30664158 | 0.73 | DYRK1A (0.55) | DYRK1AGSK3BKDM4EMEN1ALDH1A1 | |
| SCHEMBL1144415 | 0.68 | ADORA2A (0.46) | DYRK1AGSK3BMAPTNQO2 | |
| SCHEMBL5674822 | 0.68 | AHR (0.48) | GSK3BKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL4418164 | 0.67 | PDK2 (0.46) | GSK3BMAPT | |
| SCHEMBL31188776 | 0.67 | KIF11 (0.59) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL10169901 | 0.67 | DYRK1A (0.60) | DYRK1AKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3535263-B1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2020-09-30 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |