Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2759481 | 0.84 | TDP1 (0.57) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL22281944 | 0.83 | TDP1 (0.60) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL12233401 | 0.81 | TDP1 (0.67) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL15147994 | 0.80 | TDP1 (0.54) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL12331329 | 0.80 | TDP1 (0.56) | TDP1GAACA12CA1CA2 | |
| SCHEMBL992153 | 0.78 | SMN1; SMN2 (0.58) | TDP1GAACA12CA1CA2 | |
| SCHEMBL8589907 | 0.78 | ACHE (0.58) | TDP1TSHR | |
| SCHEMBL26578213 | 0.78 | ACHE (0.58) | TDP1TSHR | |
| SCHEMBL1461242 | 0.78 | GAA (0.60) | TDP1GAACA12CA1CA2 | |
| SCHEMBL3265064 | 0.77 | TDP1 (0.54) | TDP1GAACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |