Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13790335 | 0.85 | RELA (0.55) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL20283189 | 0.84 | NFE2L2 (0.50) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL13841249 | 0.82 | PIM1 (0.47) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL1045095 | 0.82 | PIM1 (0.47) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL1045096 | 0.82 | PIM1 (0.47) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL13562810 | 0.82 | PIM1 (0.47) | PIM1PIM2NFE2L2CHEK1RELA | |
| SCHEMBL4293317 | 0.81 | PIM1 (0.49) | PIM1PIM2CHEK1CHRM2CHRM1 | |
| SCHEMBL31381747 | 0.81 | PIM1 (0.49) | PIM1PIM2CHEK1CHRM2CHRM1 | |
| SCHEMBL21287982 | 0.79 | PIM1 (0.50) | PIM1PIM2CHEK1CHRM2CHRM1 | |
| SCHEMBL12760707 | 0.79 | CYP19A1 (0.55) | PIM1PIM2NFE2L2CHEK1RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |