Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28637244 | 0.87 | RAD52 (0.96) | RAD52SIGMAR1CHRM5CHRM3CXCR4 | |
| SCHEMBL6503351 | 0.87 | RAD52 (0.59) | RAD52CXCR4EPHX1GAAHRH3 | |
| SCHEMBL6493217 | 0.87 | RAD52 (0.59) | RAD52CXCR4EPHX1GAAHRH3 | |
| SCHEMBL17484488 | 0.86 | RAD52 (0.60) | RAD52CXCR4GNAI3GNAO1GNAI1 | |
| SCHEMBL20614282 | 0.85 | RAD52 (0.58) | RAD52SIGMAR1CXCR4EPHX1GAA | |
| SCHEMBL7947655 | 0.85 | RAD52 (0.58) | RAD52SIGMAR1CXCR4EPHX1GAA | |
| SCHEMBL6973435 | 0.83 | RAD52 (0.55) | RAD52SIGMAR1CXCR4EPHX1GAA | |
| SCHEMBL22123351 | 0.80 | RAD52 (0.82) | RAD52SIGMAR1CHRM5CHRM3CXCR4 | |
| SCHEMBL7511788 | 0.79 | RAD52 (0.51) | RAD52CXCR4EPHX1GAAHRH3 | |
| SCHEMBL13045564 | 0.79 | GAA (0.62) | RAD52EPHX1GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488532-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-05-09 | — | — | EP | disclosed |