Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444437 | 1.00 | S1PR4 (0.50) | S1PR4MEN1KMT2ATGFBR1RAB9A | |
| SCHEMBL12036800 | 0.81 | NNMT (0.42) | S1PR4KMT2ATGFBR1KDM4EL3MBTL1 | |
| SCHEMBL16230349 | 0.81 | S1PR4 (0.53) | S1PR4MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL16742675 | 0.81 | S1PR4 (0.34) | S1PR4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL12037052 | 0.81 | S1PR4 (0.53) | S1PR4RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL12036727 | 0.81 | AAK1 (0.41) | S1PR4SMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL30082515 | 0.81 | S1PR4 (0.34) | S1PR4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3395611 | 0.79 | KDM4E (0.52) | S1PR4MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14290550 | 0.79 | S1PR4 (0.53) | S1PR4MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15985927 | 0.78 | CCR1 (0.38) | S1PR4KDM4EALDH1A1L3MBTL1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | EMORY UNIVERSITY (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | UNIV EMORY (US) | 2020-08-27 | — | — | US | disclosed |
| WO-2019023448-A1 | NADPH OXIDASE INHIBITORS AND USES THEREOF | EMORY UNIVERSITY (US) | 2019-01-31 | — | — | WO | disclosed |
| EP-2970173-B1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD (IN) | 2018-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | NOX1, NOX3, NOX5 | S1PR4 2749/4885MEN1 4554/4885KMT2A 2871/4885 |
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | NOX1, NOX3, NOX5 | S1PR4 2749/4885MEN1 4554/4885KMT2A 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.