Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14828635 | 0.80 | CA12 (0.54) | CA12CA9MAPTTHRBF11 | |
| SCHEMBL19737508 | 0.80 | CA12 (0.50) | CA12CA9MAPTTHRBF11 | |
| SCHEMBL19737581 | 0.79 | HDAC4 (0.42) | CA12CA9MAPTTHRB | |
| SCHEMBL30022843 | 0.77 | CA12 (0.55) | CA12CA9MAPTF11AKR1B1 | |
| SCHEMBL12559818 | 0.77 | CA12 (0.55) | CA12CA9MAPTF11AKR1B1 | |
| SCHEMBL29153243 | 0.77 | CA12 (0.58) | CA12CA9MAPTF11AKR1B1 | |
| SCHEMBL21729420 | 0.76 | MCL1 (0.44) | CA12CA9MAPTTHRBEIF4A3 | |
| SCHEMBL19737649 | 0.76 | CA12 (0.36) | CA12CA9MAPTTHRBEIF4A3 | |
| SCHEMBL31058635 | 0.75 | CA12 (0.56) | CA12CA9MAPTF11AKR1B1 | |
| SCHEMBL29241812 | 0.75 | CA12 (0.56) | CA12CA9MAPTF11AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150675-A1 | COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| EP-3318557-A2 | QUINOLONE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-05-09 | — | — | EP | disclosed |