Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.58 |
| ▸ | CA9 | Q16790 | 6/20 | 0.58 |
| ▸ | F11 | P03951 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058635 | 0.82 | CA12 (0.56) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL29241812 | 0.82 | CA12 (0.56) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL12559818 | 0.81 | CA12 (0.55) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL17434592 | 0.81 | CA12 (0.55) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL29153233 | 0.81 | CA12 (0.55) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL30022843 | 0.81 | CA12 (0.55) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL31142828 | 0.81 | F11 (0.50) | CA12CA9F11AKR1B1DAO | |
| SCHEMBL31118648 | 0.77 | F11 (0.46) | CA12CA9F11AKR1B1KDM4E | |
| SCHEMBL6450437 | 0.77 | CA12 (0.50) | CA12CA9F11AKR1B1GRIN2C | |
| SCHEMBL29153229 | 0.77 | CA12 (0.50) | CA12CA9F11AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327388-A1 | QUINOLINAMINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2024-10-03 | — | — | US | disclosed |
| EP-4349831-A1 | QUINOLINAMINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| CN-117222639-A | Quinoline amine compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2022247920-A1 | QUINOLINAMINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS | 江苏恒瑞医药股份有限公司 | 2022-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327388-A1 | QUINOLINAMINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS | QARS1, THEM6, CYP4F11 | CA12 4688/4885CA9 4552/4885F11 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.