Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468359 | 0.82 | AHR (0.52) | MAPTKDM4EGAATDP1AHR | |
| SCHEMBL15828604 | 0.81 | KDM4E (0.42) | MAPTKDM4ENPC1RAB9APOLB | |
| SCHEMBL11483589 | 0.78 | HTT (0.47) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL10799076 | 0.78 | KDM4E (0.52) | MAPTKDM4ENPC1RAB9APOLB | |
| SCHEMBL13750598 | 0.74 | KDM4E (0.46) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL14822663 | 0.72 | AHR (0.51) | MAPTKDM4EGAAPOLBKMT2A | |
| SCHEMBL7921087 | 0.69 | AHR (0.46) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL22889555 | 0.69 | CYP11B2 (0.55) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13729698 | 0.69 | KDM4E (0.41) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL10987450 | 0.68 | KDM4E (0.52) | MAPTKDM4ENPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318557-A2 | QUINOLONE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-05-09 | — | — | EP | disclosed |