Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20346778 | 0.77 | TDP1 (0.30) | TDP1 | |
| SCHEMBL9175808 | 0.75 | CYP3A4 (0.33) | CYP3A4 | |
| SCHEMBL9175802 | 0.75 | CYP3A4 (0.33) | CYP3A4 | |
| SCHEMBL9170481 | 0.74 | TSHR (0.37) | CYP3A4TDP1 | |
| SCHEMBL9170486 | 0.74 | TSHR (0.37) | CYP3A4TDP1 | |
| SCHEMBL7766345 | 0.72 | KDM4E (0.32) | TDP1 | |
| SCHEMBL11667699 | 0.71 | TSHR (0.39) | CYP3A4TDP1 | |
| SCHEMBL6424852 | 0.70 | CYP3A4 (0.37) | CYP3A4TDP1 | |
| SCHEMBL6838883 | 0.70 | TSHR (0.39) | CYP3A4TDP1 | |
| SCHEMBL6363030 | 0.70 | CYP3A4 (0.37) | CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186814-A1 | TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL | SHIONOGI & CO., LTD. (JP) | 2018-07-05 | — | — | US | disclosed |
| US-20180186814-A1 | TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL | SHIONOGI & CO., LTD. (JP) | 2018-07-05 | — | — | US | disclosed |
| EP-3318567-A1 | TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL | Shionogi & Co., Ltd (JP) | 2018-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186814-A1 | TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL | SULT1E1, ABCC5, ABCC4 | CYP3A4 82/4885TDP1 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.