Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.67 |
| ▸ | KDM5A | P29375 | 4/20 | 0.67 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125325 | 0.85 | KDM4C (0.60) | KDM4CKDM5AKDM5BKDM4EMAPK1 | |
| SCHEMBL16149595 | 0.80 | KDM4C (1.00) | KDM4CKDM5AKDM5BLMNA | |
| SCHEMBL20125364 | 0.80 | KDM4C (0.65) | KDM4CKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL16149249 | 0.79 | KDM4C (0.81) | KDM4CKDM5AKDM5BKDM4ETLR8 | |
| SCHEMBL21204906 | 0.76 | KDM4C (0.70) | KDM4CKDM5AKDM5BKDM4EMAPK1 | |
| SCHEMBL7060431 | 0.73 | KDM4C (0.47) | KDM4CKDM5AKDM5BKDM4EMAPK1 | |
| SCHEMBL7608317 | 0.72 | PDE2A (0.44) | KDM4CKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL590873 | 0.70 | KDM4E (0.68) | KDM4EMAPK1NPSR1ALDH1A1TRIM24 | |
| SCHEMBL135243 | 0.69 | ALDH1A1 (0.66) | KDM4EALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL2933117 | 0.69 | KDM4E (0.55) | KDM4EMAPK1NPSR1ALDH1A1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |