SCHEMBL135243

SCHEMBL135243

COc1ccc(C=O)c(C)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.66
TRIM24 O15164 1/20 0.63
TYR P14679 1/20 0.63
TRIM33 Q9UPN9 1/20 0.63
ERN1 O75460 3/20 0.58
CYP1A2 P05177 5/20 0.50
KDM4E B2RXH2 4/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 2/20 0.50
CYP1A1 P04798 3/20 0.48
CYP1B1 Q16678 3/20 0.48
CYP2A6 P11509 1/20 0.48
LMNA P02545 1/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.45
POLB P06746 1/20 0.45
HPGD P15428 2/20 0.43
HSD17B10 Q99714 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6467176 0.85 ALDH1A1 (0.47) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL29957330 0.83 ERN1 (0.63) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL2505574 0.83 ERN1 (0.63) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL29957021 0.83 ALDH1A1 (0.70) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL12672585 0.83 ALDH1A1 (0.70) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL17106543 0.81 CYP1A2 (0.52) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL17106542 0.81 CYP1A2 (0.52) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL4517156 0.81 ALDH1A1 (0.45) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL3176504 0.80 ALDH1A1 (0.43) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL17240967 0.79 ALDH1A1 (0.47) ALDH1A1TRIM24TYRTRIM33ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 327 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114746069-A Three-step multi-tone hair dyeing method 汉高股份有限及两合公司 2022-07-12 CN claimed
US-20090076168-A1 AMINE-BASED AND IMINE-BASED POLYMERS, USES AND PREPARATION THEREOF LE TIEN CANH 2009-03-19 US claimed
WO-2006092057-A1 AMINE-BASED AND IMINE-BASED POLYMERS, USES AND PREPARATION THEREOF LABORATOIRES MAUVES INC. (CA) 2006-09-08 WO claimed
US-4727079-A Brain-specific dopaminergic activity involving dihydropyridine carboxamides, dihydroquinoline and isoquinoline carboxamides UNIVERSITY OF FLORIDA (US) 1988-02-23 US claimed
EP-3573972-B1 RORGAMMA MODULATORS AND USES THEREOF GENFIT (FR) 2026-01-14 EP disclosed
US-20250326744-A1 PIPERAZINE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FUJIFILM CORPORATION (JP) 2025-10-23 US disclosed
CN-119816484-A Novel piperazine derivative or salt thereof and pharmaceutical composition 富士胶片株式会社 2025-04-11 CN disclosed
WO-2024043334-A1 NOVEL PIPERAZINE DERIVATIVE OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION 富士フイルム株式会社 2024-02-29 WO disclosed
US-20240016191-A1 METHOD FOR PREPARING AGROCYBE CYLINDRACEA FERMENTED KUDZUVINE ROOT AND COIX SEEDS BEVERAGE GUIZHOU UNIVERSITY (CN) 2024-01-18 US disclosed
US-11858889-B2 Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease THE TRUSTEES OF INDIANA UNIVERSITY (US) 2024-01-02 US disclosed
US-11858889-B2 Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease THE TRUSTEES OF INDIANA UNIVERSITY (US) 2024-01-02 US disclosed
US-11858889-B2 Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease THE TRUSTEES OF INDIANA UNIVERSITY (US) 2024-01-02 US disclosed
US-4145441-A SYMPATHOMIMETIC AMINES EXHIBITING ANTI-HEMORRHOIDAL ACTIVITY INTERX RESEARCH CORPORATION (US) 1979-03-20 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed
US-4129723-A Bichromophoric benzoxazole-styrene ester and amide ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-12-12 US disclosed
US-4094983-A \"KETO\" SYMPATHOMIMETIC AMINES INTERX RESEARCH CORPORATION (US) 1978-06-13 US disclosed
US-4070339-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4062800-A Bichromophoric benzoxazole-styrene ester and amide ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-13 US disclosed
US-4058642-A HYPERTENSIVE BOEHRINGER INGELHEIM GMBH (DT) 1977-11-15 US disclosed
US-4035405-A Novel synthesis for preparing the hydrochloride salt of selected catecholamine derivatives INTERX RESEARCH CORPORATION (US) 1977-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11858889-B2 Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease ADM2, DDAH1, BHMT ALDH1A1 336/4885TRIM24 2145/4885TYR 2621/4885
US-20090076168-A1 AMINE-BASED AND IMINE-BASED POLYMERS, USES AND PREPARATION THEREOF SMS, INMT, SRM ALDH1A1 117/4885TRIM24 3347/4885TYR 12/4885
US-20250326744-A1 PIPERAZINE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION ABCB11, ABCC1, SLC11A2 ALDH1A1 774/4885TRIM24 4520/4885TYR 845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.