Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 10/20 | 0.62 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.62 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.41 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125300 | 0.85 | KDM5B (0.64) | KDM5AKDM5BKDM4CKDM4ACCR1 | |
| SCHEMBL16150864 | 0.77 | KDM5A (1.00) | KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL20125476 | 0.76 | KDM4C (0.70) | KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL20125330 | 0.73 | KDM5B (0.62) | KDM5AKDM5BKDM4CKDM4ACCR1 | |
| SCHEMBL16150913 | 0.73 | KDM5A (0.73) | KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL20125363 | 0.73 | KDM5B (0.60) | KDM5AKDM5BKDM4CKDM4ACYP19A1 | |
| SCHEMBL20125266 | 0.70 | KDM5B (0.61) | KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL20125258 | 0.69 | KDM5B (0.59) | KDM5AKDM5BKDM4CKDM4ACCR1 | |
| SCHEMBL20125328 | 0.68 | KDM5B (0.68) | KDM5AKDM5BKDM4CKDM4APTPN11 | |
| SCHEMBL30053741 | 0.67 | KDM5A (0.50) | KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |