Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.68 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.68 |
| ▸ | KDM5A | P29375 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125330 | 0.84 | KDM5B (0.62) | KDM5BKDM4CKDM5AKDM4APTPN11 | |
| SCHEMBL16157346 | 0.77 | KDM5B (0.78) | KDM5BKDM4CKDM5AKDM4A | |
| SCHEMBL20125409 | 0.69 | KDM5B (0.65) | KDM5BKDM4CKDM5AKDM4A | |
| SCHEMBL20125322 | 0.68 | KDM5A (0.62) | KDM5BKDM4CKDM5AKDM4APTPN11 | |
| SCHEMBL13714108 | 0.67 | TSHR (0.51) | KDM5BKDM4CCYP3A4TSHRCYP2C19 | |
| SCHEMBL20125363 | 0.67 | KDM5B (0.60) | KDM5BKDM4CKDM5AKDM4ACYP19A1 | |
| SCHEMBL20125477 | 0.67 | KDM4A (0.65) | KDM5BKDM4CKDM5AKDM4A | |
| SCHEMBL16150526 | 0.65 | KDM5A (1.00) | KDM5BKDM4CKDM5AKDM4A | |
| SCHEMBL20125300 | 0.65 | KDM5B (0.64) | KDM5BKDM4CKDM5AKDM4A | |
| SCHEMBL20125266 | 0.64 | KDM5B (0.61) | KDM5BKDM4CKDM5AKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |