Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.62 |
| ▸ | KDM5A | P29375 | 13/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125349 | 0.87 | KDM4C (0.58) | KDM4CKDM5ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16148957 | 0.77 | KDM4C (1.00) | KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL20125360 | 0.74 | KDM4C (0.65) | KDM4CKDM5AL3MBTL1KDM4EMAPK1 | |
| SCHEMBL16149482 | 0.73 | KDM4C (0.76) | KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL20125475 | 0.70 | KDM5A (0.56) | KDM4CKDM5AKDM4EMAPK1KDM5B | |
| SCHEMBL20125287 | 0.70 | KDM5A (0.33) | KDM5AL3MBTL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL20125307 | 0.66 | KDM5A (0.71) | KDM4CKDM5AALDH1A1KDM5BKDM4A | |
| SCHEMBL20125370 | 0.65 | KDM5A (0.62) | KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL20125340 | 0.65 | KDM4C (0.64) | KDM4CKDM5AKDM4EMAPK1KDM5B | |
| SCHEMBL15841249 | 0.64 | MAPT (0.53) | CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |