Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 12/20 | 0.69 |
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.69 |
| ▸ | KDM4A | O75164 | 9/20 | 0.69 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125358 | 0.85 | KDM5A (0.53) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL16157355 | 0.82 | KDM5A (1.00) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL20125365 | 0.80 | KDM5A (0.56) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL16157411 | 0.79 | KDM5A (0.78) | KDM5AKDM5BKDM4AKDM4CCSF1R | |
| SCHEMBL20125409 | 0.77 | KDM5B (0.65) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL20125343 | 0.75 | KDM4C (0.49) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL20125359 | 0.74 | KDM5B (0.66) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL20125363 | 0.70 | KDM5B (0.60) | KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL9901133 | 0.69 | IDO1 (0.51) | KDM5AKDM5BKDM4AIDO1 | |
| SCHEMBL20125427 | 0.69 | KDM5A (0.47) | KDM5AKDM5BKDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |