Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019261 | 0.89 | PIK3CD (0.44) | PIK3CDBCL2CDK1KDM4EALDH1A1 | |
| SCHEMBL2015599 | 0.88 | BCL2 (0.36) | PIK3CDBCL2 | |
| SCHEMBL12491178 | 0.77 | BCL2 (0.47) | PIK3CDBCL2KDM4E | |
| SCHEMBL2016661 | 0.77 | PIK3CD (0.36) | PIK3CDBCL2KDM4EMAPT | |
| SCHEMBL2012742 | 0.75 | PIK3CD (0.46) | PIK3CDBCL2KDM4E | |
| SCHEMBL12403232 | 0.74 | BCL2 (0.48) | PIK3CDBCL2KDM4E | |
| SCHEMBL2012486 | 0.74 | PIK3CD (0.46) | PIK3CDBCL2LMNAMAPTHTT | |
| SCHEMBL2015596 | 0.72 | BCL2 (0.48) | PIK3CDBCL2LMNAHTT | |
| Trifluoroacetic Acid SCHEMBL2012078 | 0.72 | BCL2 (0.41) | PIK3CDBCL2LMNA | |
| Trifluoroacetic Acid SCHEMBL2013841 | 0.69 | BCL2 (0.42) | PIK3CDBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |