Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2013841 | 0.92 | BCL2 (0.42) | BCL2PIK3CDNT5ETAAR1GRIN2B | |
| SCHEMBL12491178 | 0.91 | BCL2 (0.47) | BCL2PIK3CDNT5ETAAR1CYP3A4 | |
| SCHEMBL2019261 | 0.82 | PIK3CD (0.44) | BCL2PIK3CDNT5EGRIN2BCYP3A4 | |
| SCHEMBL12403232 | 0.82 | BCL2 (0.48) | BCL2PIK3CDNT5ETAAR1GRIN2B | |
| SCHEMBL2016433 | 0.81 | TAAR1 (0.43) | BCL2PIK3CDTAAR1GRIN2BCYP3A4 | |
| SCHEMBL2015599 | 0.81 | BCL2 (0.36) | BCL2PIK3CDTAAR1 | |
| Trifluoroacetic Acid SCHEMBL2012076 | 0.81 | BCL2 (0.53) | BCL2PIK3CDNT5EGRIN2BSLC16A3 | |
| SCHEMBL2012080 | 0.80 | BCL2 (0.41) | BCL2PIK3CDNT5EGRIN2BICMT | |
| Trifluoroacetic Acid SCHEMBL2038097 | 0.79 | PIK3CD (0.49) | BCL2PIK3CDLRRK2NR1H2 | |
| SCHEMBL2015779 | 0.77 | PIK3CD (0.44) | PIK3CDTAAR1CYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |