Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001300 | 0.89 | NPSR1 (0.57) | ALDH1A1PDE10APOLBTRPV1MEN1 | |
| SCHEMBL29133299 | 0.88 | POLB (0.47) | ALDH1A1PDE10APOLBTRPV1MEN1 | |
| SCHEMBL10651130 | 0.85 | ALDH1A1 (0.45) | ALDH1A1PDE10APOLBTRPV1MEN1 | |
| SCHEMBL30113041 | 0.81 | PDE10A (0.45) | ALDH1A1PDE10APOLBMEN1KMT2A | |
| SCHEMBL1333048 | 0.79 | PDE10A (0.49) | ALDH1A1PDE10APOLBMEN1KMT2A | |
| SCHEMBL17806134 | 0.76 | PDE10A (0.46) | ALDH1A1PDE10APOLBMEN1KMT2A | |
| SCHEMBL8564975 | 0.75 | PDE10A (0.51) | ALDH1A1PDE10APOLBMEN1KMT2A | |
| SCHEMBL1269240 | 0.75 | RAB9A (0.50) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL29389125 | 0.75 | RAB9A (0.50) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL2001303 | 0.74 | ALDH1A1 (0.41) | ALDH1A1POLBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513089-A1 | 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT | Johannes Gutenberg-Universität Mainz (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073092-A1 | 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT | Johannes Gutenberg-Universität Mainz (DE) | 2011-06-23 | — | — | WO | disclosed |