SCHEMBL2012878

SCHEMBL2012878

Oc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 1.00
GAA P10253 3/20 1.00
ATM Q13315 1/20 1.00
MAPKAPK2 P49137 1/20 0.67
CYP2D6 P10635 8/20 0.65
CYP1A2 P05177 8/20 0.65
TDP1 Q9NUW8 3/20 0.62
KMT2A Q03164 1/20 0.62
RAD52 P43351 2/20 0.60
GFER P55789 1/20 0.60
CYP2C8 P10632 5/20 0.60
CYP2C19 P33261 5/20 0.60
KCNH2 Q12809 5/20 0.60
CYP2C9 P11712 3/20 0.60
CYP3A4 P08684 3/20 0.60
APP P05067 2/20 0.60
OPRM1 P35372 2/20 0.60
ABCB11 O95342 1/20 0.60
CHRM2 P08172 1/20 0.60
HTR1A P08908 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30362771 1.00 MAPT (1.00) MAPTGAAATMMAPKAPK2CYP2D6
SCHEMBL9452123 0.85 MAPT (0.74) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL12430792 0.85 MAPT (0.74) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL5309628 0.85 MAPT (0.74) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL21346893 0.85 MAPT (0.74) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL30179800 0.85 GAA (0.73) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL2011565 0.85 GAA (0.73) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL21121733 0.85 MAPT (0.73) MAPTGAAATMCYP2D6CYP1A2
SCHEMBL9480795 0.83 MAPT (0.71) MAPTGAAATMMAPKAPK2CYP2D6
SCHEMBL27878984 0.83 MAPT (0.71) MAPTGAAATMMAPKAPK2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3481806-B1 4-ANILINO-QUINOLINE COMPOUNDS AS ANTI-CANCER AGENTS INST NAT SANTE RECH MED (FR) 2023-06-07 EP claimed
EP-3735407-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) 2020-11-11 EP claimed
WO-2019134969-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2019-07-11 WO claimed
US-20160031854-A1 ACTIVATION OR REACTIVATION OF ACHE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-02-04 US claimed
WO-2014210168-A1 ACTIVATION OR REACTIVATION OF ACHE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-12-31 WO claimed
WO-2014113495-A1 ACTIVATION OR REACTIVATION OF ACHE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-07-24 WO claimed
US-20230301981-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2023-09-28 US disclosed
US-20230301981-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2023-09-28 US disclosed
EP-4164646-A1 TLR7/8 ANTAGONISTS AND USES THEREOF Merck Patent GmbH (DE) 2023-04-19 EP disclosed
WO-2021257273-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2021-12-23 WO disclosed
WO-2021257273-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2021-12-23 WO disclosed
EP-3735407-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) 2020-11-11 EP disclosed
WO-2019173482-A1 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS Sanford Burnham Prebys Medical Discovery Institute (US) 2019-09-12 WO disclosed
US-20120283256-A1 NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS UNIVERSITE LILLE 1 - SCIENCES ET TECHNOLOGIES (FR) 2012-11-08 US disclosed
US-20120283256-A1 NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS UNIVERSITE LILLE 1 - SCIENCES ET TECHNOLOGIES (FR) 2012-11-08 US disclosed
US-20120283256-A1 NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS UNIVERSITE LILLE 1 - SCIENCES ET TECHNOLOGIES (FR) 2012-11-08 US disclosed
EP-2513062-A1 7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS Institut National de la Santé et de la Recherche Médicale (FR) 2012-10-24 EP disclosed
WO-2011073322-A1 7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2011-06-23 WO disclosed
WO-2011073322-A1 7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2011-06-23 WO disclosed
US-4421920-A AMINATION, AROMATIZATION, RUTHENIUM CATALYST RHONE-POULENC SANTE (FR) 1983-12-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120283256-A1 NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS APP, BACE1, PSEN1 MAPT 20/4885GAA 537/4885ATM 2757/4885
US-20230301981-A1 TLR7/8 ANTAGONISTS AND USES THEREOF TLR7, TLR8, TLR9 MAPT 3896/4885GAA 1014/4885ATM 690/4885
US-20160031854-A1 ACTIVATION OR REACTIVATION OF ACHE ACHE, BCHE, CHAT MAPT 2917/4885GAA 337/4885ATM 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.