Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128892 | 0.97 | IRAK4 (0.52) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| SCHEMBL30432431 | 0.96 | CRBN (0.53) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| SCHEMBL23729483 | 0.95 | CRBN (0.54) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| SCHEMBL23705600 | 0.93 | CRBN (0.56) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| Formic Acid SCHEMBL23705587 | 0.91 | CRBN (0.52) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| Formic Acid SCHEMBL30058723 | 0.91 | CRBN (0.52) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| Formic Acid SCHEMBL23705607 | 0.89 | CRBN (0.53) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| Formic Acid SCHEMBL29617066 | 0.89 | CRBN (0.53) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| SCHEMBL22907356 | 0.89 | CRBN (0.53) | IRAK4LRRK2CRBNDDB1ALDH1A1 | |
| SCHEMBL20128894 | 0.89 | MAOA (0.57) | IRAK4LRRK2CRBNDDB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | IRAK4 3852/4885LRRK2 40/4885CRBN 3/4885 |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | IRAK4 4093/4885LRRK2 94/4885CRBN 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.