Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WIZ | O95785 | 6/20 | 0.59 |
| ▸ | MAOA | P21397 | 4/20 | 0.56 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24079649 | 0.94 | WIZ (0.63) | WIZTNFCRBNHRH3IKZF2 | |
| SCHEMBL25087643 | 0.93 | TNF (0.62) | WIZTNFCRBNHRH3IKZF2 | |
| SCHEMBL24160153 | 0.86 | CRBN (0.54) | WIZTNFCRBNIKZF2 | |
| SCHEMBL25035421 | 0.86 | CRBN (0.61) | WIZTNFCRBNIKZF2 | |
| SCHEMBL22536267 | 0.86 | CRBN (0.58) | WIZTNFCRBNIKZF2 | |
| SCHEMBL29311129 | 0.86 | CRBN (0.58) | WIZTNFCRBNIKZF2 | |
| SCHEMBL20231502 | 0.85 | CRBN (0.60) | WIZCRBNIKZF2 | |
| SCHEMBL22360830 | 0.85 | CRBN (0.63) | WIZCRBNIKZF2 | |
| SCHEMBL20120692 | 0.85 | CRBN (0.63) | WIZCRBNIKZF2 | |
| SCHEMBL24500580 | 0.85 | CRBN (0.63) | WIZCRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | WIZ 2197/4885MAOA 2592/4885MAOB 2985/4885 |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | WIZ 1213/4885MAOA 3431/4885MAOB 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.