Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129265 | 0.83 | DGAT1 (0.35) | DGAT1 | |
| SCHEMBL31239610 | 0.82 | TDO2 (0.40) | DGAT1HCRTR1HCRTR2ATRTDO2 | |
| SCHEMBL31401100 | 0.82 | KCNH2 (0.42) | DGAT1HSD11B1HCRTR1HCRTR2HSD11B2 | |
| SCHEMBL31239617 | 0.82 | ATR (0.38) | DGAT1DDB1CRBNHCRTR1HCRTR2 | |
| SCHEMBL22711853 | 0.81 | DGAT1 (0.43) | DGAT1HSD11B1HCRTR1HCRTR2HSD11B2 | |
| SCHEMBL30884069 | 0.81 | DGAT1 (0.43) | DGAT1HSD11B1HCRTR1HCRTR2HSD11B2 | |
| SCHEMBL30314525 | 0.79 | SLC6A4 (0.43) | DGAT1HTR2CSLC6A4HTR2BHTR6 | |
| SCHEMBL10078051 | 0.79 | SLC6A4 (0.43) | DGAT1HTR2CSLC6A4HTR2BHTR6 | |
| Hydrochloric Acid SCHEMBL31347800 | 0.78 | SLC6A4 (0.42) | DGAT1HTR2CSLC6A4HTR2BHTR6 | |
| Hydrochloric Acid SCHEMBL517567 | 0.78 | SLC6A4 (0.42) | DGAT1HTR2CSLC6A4HTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | DGAT1 4519/4885HSD11B1 4020/4885DDB1 433/4885 |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | DGAT1 4651/4885HSD11B1 4133/4885DDB1 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.