Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917383 | 1.00 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL2016670 | 0.91 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL6918283 | 0.91 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL13138950 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL6919279 | 0.86 | HCRTR1 (0.45) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL13138938 | 0.84 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL2015176 | 0.84 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL13138972 | 0.83 | HCRTR1 (0.50) | HCRTR1HCRTR2SMN1; SMN2HPGDTSHR | |
| SCHEMBL13138955 | 0.83 | GAA (0.42) | HCRTR1HCRTR2SMN1; SMN2TSHRNPC1 | |
| SCHEMBL13138957 | 0.83 | C5AR1 (0.41) | HCRTR1HCRTR2SMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |