Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918283 | 1.00 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1MAOBKMT2A | |
| SCHEMBL6917383 | 0.91 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1KMT2APDE10A | |
| SCHEMBL2013191 | 0.91 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1KMT2APDE10A | |
| SCHEMBL13138950 | 0.87 | HCRTR1 (0.43) | HCRTR1HCRTR2ALDH1A1PDE10ASMN1; SMN2 | |
| SCHEMBL13138972 | 0.84 | HCRTR1 (0.50) | HCRTR1HCRTR2ALDH1A1KMT2APDE10A | |
| SCHEMBL6919279 | 0.83 | HCRTR1 (0.45) | HCRTR1HCRTR2ALDH1A1PDE10ASMN1; SMN2 | |
| SCHEMBL13138938 | 0.81 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1PDE10ASMN1; SMN2 | |
| SCHEMBL2015176 | 0.81 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1PDE10ASMN1; SMN2 | |
| SCHEMBL2014119 | 0.81 | HCRTR1 (0.59) | HCRTR1HCRTR2MAOBKMT2ANPC1 | |
| SCHEMBL13138955 | 0.81 | GAA (0.42) | HCRTR1HCRTR2PDE10ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |