Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014681 | 1.00 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2P2RX7OPRM1 | |
| SCHEMBL2014592 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2P2RX7OPRM1 | |
| SCHEMBL2011408 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2OPRM1OPRK1 | |
| SCHEMBL2051291 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2P2RX7OPRM1 | |
| SCHEMBL2013196 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2LMNAALDH1A1MAPT | |
| SCHEMBL2010539 | 0.81 | HCRTR1 (0.63) | HCRTR1HCRTR2P2RX7SMN1; SMN2HPGD | |
| SCHEMBL2012798 | 0.81 | HCRTR1 (0.48) | HCRTR1HCRTR2P2RX7OPRM1OPRK1 | |
| SCHEMBL2017304 | 0.80 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2OPRM1OPRK1 | |
| SCHEMBL6919106 | 0.80 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2OPRM1OPRK1 | |
| SCHEMBL2013858 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2P2RX7OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |