Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 3/20 | 0.39 |
| ▸ | MPI | P34949 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | HUWE1 | Q7Z6Z7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017831 | 0.86 | METAP2 (0.38) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2017050 | 0.85 | SLC40A1 (0.40) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2051951 | 0.85 | PIK3CD (0.35) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2012273 | 0.84 | HTT (0.39) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2012342 | 0.83 | MAPT (0.42) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2012932 | 0.82 | ABCC1 (0.33) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2163159 | 0.82 | PIK3CD (0.43) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2013837 | 0.82 | BTK (0.37) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2014977 | 0.82 | SLC40A1 (0.38) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2014980 | 0.82 | SLC40A1 (0.38) | LMNAMAPTKDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |