SCHEMBL20132103

SCHEMBL20132103

CC(C)(C)OC(=O)Nc1cccc(Cc2ccc(C=O)cc2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 2/20 0.51
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
MAPK14 Q16539 1/20 0.46
USP30 Q70CQ3 1/20 0.45
AURKA O14965 1/20 0.45
RPS6KB1 P23443 1/20 0.45
SIRT2 Q8IXJ6 1/20 0.43
PPARA Q07869 2/20 0.42
PPARG P37231 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
SAE1 Q9UBE0 1/20 0.42
UBA2 Q9UBT2 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29768878 1.00 CYP17A1 (0.51) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL30632219 0.93 CYP17A1 (0.48) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL30108127 0.93 CYP17A1 (0.48) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL26507059 0.93 CYP17A1 (0.48) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL20132094 0.91 HDAC3 (0.49) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL25128919 0.88 CYP17A1 (0.57) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL20132261 0.86 HDAC3 (0.45) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL30040901 0.86 HDAC3 (0.45) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL24622290 0.86 CYP17A1 (0.52) CYP17A1HDAC3HDAC1HDAC2HDAC8
SCHEMBL29768862 0.86 CYP17A1 (0.52) CYP17A1HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041781-A1 NOVEL GLUCOCORTICOID RECEPTOR AGONISTS AND IMMUNOCONJUGATES THEREOF ADCENTRX THERAPEUTICS INC (US) 2026-02-12 US disclosed
EP-4587030-A2 NOVEL GLUCOCORTICOID RECEPTOR AGONISTS AND IMMUNOCONJUGATES THEREOF Adcentrx Therapeutics Inc. (US) 2025-07-23 EP disclosed
EP-4558511-A2 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF Firefly Bio, Inc. (US) 2025-05-28 EP disclosed
US-20240218011-A1 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF FIREFLY BIO, INC. 2024-07-04 US disclosed
US-20240218011-A1 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF FIREFLY BIO, INC. 2024-07-04 US disclosed
WO-2024059237-A2 NOVEL GLUCOCORTICOID RECEPTOR AGONISTS AND IMMUNOCONJUGATES THEREOF ADCENTRX THERAPEUTICS INC. (US) 2024-03-21 WO disclosed
WO-2024020164-A2 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF FIREFLY BIO, INC. (US) 2024-01-25 WO disclosed
WO-2024020164-A2 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF FIREFLY BIO, INC. (US) 2024-01-25 WO disclosed
WO-2023245106-A1 ANTI-CD19 ANTIBODY DRUG CONJUGATES ABBVIE BIOTHERAPEUTICS INC. (US) 2023-12-21 WO disclosed
US-20230310634-A1 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF IMMUNEXT INC (US) 2023-10-05 US disclosed
EP-3658192-B1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC (US) 2021-04-28 EP disclosed
EP-3464318-B1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC (US) 2021-04-21 EP disclosed
US-20210015938-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC. (US) 2021-01-21 US disclosed
US-20200338208-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC. (US) 2020-10-29 US disclosed
US-10772970-B2 Glucocorticoid receptor agonist and immunoconjugates thereof ABBVIE INC. (US) 2020-09-15 US disclosed
US-10668167-B2 Glucocorticoid receptor agonist and immunoconjugates thereof ABBVIE INC. (US) 2020-06-02 US disclosed
US-20190262465-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC. (US) 2019-08-29 US disclosed
US-20190167804-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC. 2019-06-06 US disclosed
CN-109476699-A Glucocorticoid receptor agonist and its immune conjugate 艾伯维公司 2019-03-15 CN disclosed
US-20180126000-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF ABBVIE INC. (US) 2018-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10772970-B2 Glucocorticoid receptor agonist and immunoconjugates thereof NR3C1, NR3C2, MC2R CYP17A1 167/4885HDAC3 957/4885HDAC1 1711/4885
US-20180126000-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 256/4885HDAC3 1200/4885HDAC1 1688/4885
US-20200338208-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 256/4885HDAC3 1200/4885HDAC1 1688/4885
US-20240218011-A1 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 264/4885HDAC3 1371/4885HDAC1 1432/4885
US-10668167-B2 Glucocorticoid receptor agonist and immunoconjugates thereof NR3C1, NR3C2, MC2R CYP17A1 256/4885HDAC3 1200/4885HDAC1 1688/4885
US-20190167804-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 167/4885HDAC3 957/4885HDAC1 1711/4885
US-20230310634-A1 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF CD47, CLTA, FCGR2A CYP17A1 1102/4885HDAC3 718/4885HDAC1 1454/4885
US-20190262465-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 256/4885HDAC3 1200/4885HDAC1 1688/4885
US-20260041781-A1 NOVEL GLUCOCORTICOID RECEPTOR AGONISTS AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 170/4885HDAC3 652/4885HDAC1 1183/4885
US-20210015938-A1 GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF NR3C1, NR3C2, MC2R CYP17A1 167/4885HDAC3 957/4885HDAC1 1711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.