Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.38 |
| ▸ | GYS1 | P13807 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012748 | 0.88 | PTGER1 (0.48) | MRGPRX4PTGER1MAOBMAPTMAPK1 | |
| SCHEMBL2012939 | 0.86 | GYS1 (0.48) | MRGPRX4PTGER1MAOBGYS1 | |
| SCHEMBL2011729 | 0.80 | GYS1 (0.54) | MAOBGYS1 | |
| SCHEMBL15309708 | 0.79 | MAPT (0.51) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL12600498 | 0.73 | MRGPRX4 (0.60) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL15309905 | 0.71 | ABCB1 (0.50) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2010257 | 0.70 | GYS1 (0.68) | GYS1 | |
| SCHEMBL2013211 | 0.70 | GYS1 (0.38) | MRGPRX4MAOBMAPTMAPK1TDP1 | |
| SCHEMBL15310220 | 0.70 | L3MBTL1 (0.46) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2012370 | 0.69 | GYS1 (0.52) | MAOBGYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011067266-A1 | CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-09 | — | — | WO | disclosed |