Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | AGER | Q15109 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352185 | 0.85 | TRPM5 (0.49) | TRPM5ADORA2AAGERNPC1RAB9A | |
| SCHEMBL20132367 | 0.82 | ADORA2A (0.48) | HDAC6HDAC1HDAC8TRPM5ADORA2A | |
| SCHEMBL3636017 | 0.80 | ADORA2A (0.48) | TRPM5ADORA2AAGERCYP2C19 | |
| SCHEMBL7444679 | 0.78 | KLK1 (0.53) | TRPM5 | |
| SCHEMBL2872492 | 0.76 | HDAC4 (0.50) | HDAC6HDAC1HDAC10HDAC11HDAC8 | |
| SCHEMBL6297758 | 0.75 | CYP2C19 (0.57) | TRPM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2718512 | 0.75 | MAOB (0.55) | TRPM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7848752 | 0.75 | NPC1 (0.57) | HDAC6ADORA2AAGERMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL6297635 | 0.74 | CYP2C19 (0.56) | TRPM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3604257 | 0.73 | HDAC6 (0.52) | HDAC6HDAC1HDAC10HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538084-B1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | ACETYLON PHARMACEUTICALS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| US-10927072-B2 | Phenyl and pyridinyl hydroxamic acids | ACETYLON PHARMACEUTICALS, INC. (US) | 2021-02-23 | — | — | US | disclosed |
| US-10370324-B2 | Phenyl and pyridinyl hydroxamic acids | ACETYLON PHARMACEUTICALS, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180127356-A1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | ACETYLON PHARMACEUTICALS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370324-B2 | Phenyl and pyridinyl hydroxamic acids | HDAC6, HDAC1, HDAC5 | HDAC6 1/4885HDAC1 2/4885HDAC10 11/4885 |
| US-10927072-B2 | Phenyl and pyridinyl hydroxamic acids | HDAC6, HDAC1, HDAC5 | HDAC6 1/4885HDAC1 2/4885HDAC10 11/4885 |
| US-20180127356-A1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | HDAC6, HDAC1, HDAC5 | HDAC6 1/4885HDAC1 2/4885HDAC10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.