SCHEMBL201335

SCHEMBL201335

NC(=O)c1c(F)ccc(OCc2nc(-c3cccc([N+](=O)[O-])c3)no2)c1F

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.64
SMN1; SMN2 Q16637 4/20 0.60
MAPT P10636 7/20 0.56
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
HDAC1 Q13547 3/20 0.49
HDAC2 Q92769 3/20 0.49
HDAC8 Q9BY41 2/20 0.49
LMNA P02545 1/20 0.49
HTT P42858 1/20 0.49
GSTP1 P09211 2/20 0.45
RAB9A P51151 5/20 0.44
NPC1 O15118 4/20 0.44
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.43
TP53 P04637 1/20 0.43
NFKB1 P19838 1/20 0.41
CASP3 P42574 1/20 0.41
NFKB2 Q00653 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL203371 0.87 MAPT (0.47) L3MBTL1SMN1; SMN2MAPTLMNAGSTP1
SCHEMBL203805 0.86 FFAR1 (0.56) L3MBTL1SMN1; SMN2MAPTKMT2ALMNA
SCHEMBL203129 0.85 MAPT (0.53) L3MBTL1SMN1; SMN2MAPTLMNAHTT
SCHEMBL2707332 0.84 MAPT (0.49) L3MBTL1SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL202596 0.84 FFAR1 (0.59) L3MBTL1SMN1; SMN2MAPTGSTP1MAPK1
SCHEMBL202214 0.84 MAPT (0.58) L3MBTL1SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL201796 0.81 GSTP1 (0.52) L3MBTL1SMN1; SMN2MAPTLMNAHTT
SCHEMBL202105 0.81 GSTP1 (0.55) L3MBTL1SMN1; SMN2MAPTLMNAHTT
SCHEMBL203466 0.81 KDM4E (0.56) L3MBTL1SMN1; SMN2MAPTKMT2AHDAC1
SCHEMBL2705735 0.80 MAPT (0.48) L3MBTL1SMN1; SMN2MAPTLMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122918-A1 ANTIBACTERIAL AGENTS ALK, ROS1, ARG1 L3MBTL1 297/4885SMN1; SMN2 3366/4885MAPT 4688/4885
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 L3MBTL1 703/4885SMN1; SMN2 1208/4885MAPT 4784/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 L3MBTL1 377/4885SMN1; SMN2 2959/4885MAPT 4744/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 L3MBTL1 703/4885SMN1; SMN2 1208/4885MAPT 4784/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 L3MBTL1 703/4885SMN1; SMN2 1208/4885MAPT 4784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.